PittsburghV1, Main, Exploration, bibRecord, 004D93

Therapeutic Targets in Heart Failure: Refocusing on the Myocardial Interstitium

Identifieur interne : 004D93 ( Main/Exploration ); précédent : 004D92; suivant : 004D94

Therapeutic Targets in Heart Failure: Refocusing on the Myocardial Interstitium

Auteurs : Erik B. Schelbert [États-Unis] ; Gregg C. Fonarow [États-Unis] ; Robert O. Bonow [États-Unis] ; Javed Butler [États-Unis] ; Mihai Gheorghiade [États-Unis]

Source :

Journal of the American College of Cardiology [ 0735-1097 ] ; 2014.

RBID : Pascal:14-0162887

Descripteurs français

Pascal (Inist)
- Insuffisance cardiaque, Pathologie de l'appareil circulatoire, Traitement, Cible, Myocarde, Appareil circulatoire, Cardiologie.

English descriptors

KwdEn :
- Cardiology, Cardiovascular disease, Circulatory system, Heart failure, Myocardium, Target, Treatment.

Abstract

New therapeutic targets, agents, and strategies are needed to prevent and treat heart failure (HF) after a decade of failed research efforts to improve long-term patient outcomes, especially in patients after hospitalization for HF. Conceptually, an accurate assessment of left ventricular structure is an essential step in the development of novel therapies because heterogeneous pathophysiologies underlie chronic HF and hospitalization for HF. Improved left ventricular characterization permits the identification and targeting of the intrinsic fundamental disease-modifying pathways that culminate in HF. Interstitial heart disease is one such pathway, characterized by extracellular matrix (ECM) expansion that is associated with mechanical, electrical, and vasomotor dysfunction and adverse outcomes. Previous landmark trials that appear to treat interstitial heart disease were effective in improving outcomes. Advances in cardiovascular magnetic resonance now enable clinicians and researchers to assess the interstitium and quantify ECM expansion using extracellular volume fraction measures and other derangements in cardiovascular structure. These capabilities may provide a mechanistic platform to advance understanding of the role of the ECM, foster the development of novel therapeutics, and target specific disease-modifying pathways intrinsic to the ventricle. Refocusing on the interstitium may potentially improve care through the identification and targeted treatment of key patient subgroups.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">New therapeutic targets, agents, and strategies are needed to prevent and treat heart failure (HF) after a decade of failed research efforts to improve long-term patient outcomes, especially in patients after hospitalization for HF. Conceptually, an accurate assessment of left ventricular structure is an essential step in the development of novel therapies because heterogeneous pathophysiologies underlie chronic HF and hospitalization for HF. Improved left ventricular characterization permits the identification and targeting of the intrinsic fundamental disease-modifying pathways that culminate in HF. Interstitial heart disease is one such pathway, characterized by extracellular matrix (ECM) expansion that is associated with mechanical, electrical, and vasomotor dysfunction and adverse outcomes. Previous landmark trials that appear to treat interstitial heart disease were effective in improving outcomes. Advances in cardiovascular magnetic resonance now enable clinicians and researchers to assess the interstitium and quantify ECM expansion using extracellular volume fraction measures and other derangements in cardiovascular structure. These capabilities may provide a mechanistic platform to advance understanding of the role of the ECM, foster the development of novel therapeutics, and target specific disease-modifying pathways intrinsic to the ventricle. Refocusing on the interstitium may potentially improve care through the identification and targeted treatment of key patient subgroups.</div>
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Therapeutic Targets in Heart Failure: Refocusing on the Myocardial Interstitium

Therapeutic Targets in Heart Failure: Refocusing on the Myocardial Interstitium

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri